2006: Japanese experts Shinya Yamanaka and Kazutoshi Takashi publish a paper describing the induction of pluripotent stem cells from cultures of Grownup mouse fibroblasts.Culturing of pluripotent stem cells in vitro. 3 days just after fertilization, totipotent cells are shaped. Blastocysts with ICM are formed to the sixth day after fertilization. P

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